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  • Cross-species recognition and molecular basis of SARS-CoV-2 . . .
    The cellular ACE2 receptor is one of the key determinants of the host range Here, we found that ACE2s from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain (RBD) of both SARS-CoV and SARS-CoV-2 and facilitate the transduction of SARS-CoV and SARS-CoV-2 pseudoviruses into ACE2-expressing cells
  • Genome-wide bioinformatic analyses predict key host and viral . . .
    The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China Here we analyzed public host and viral RNA sequencing data to better understand how SARS-CoV-2 interacts with human respiratory cells We iden …
  • Innate immune evasion strategies of SARS-CoV-2 - Nature
    The genome of SARS-CoV-2, like all members of its genus, is ~30,000 nucleotides in length, with an invariant gene order Starting at the 5′ end are the genes for replicase and other non
  • Can We Predict Which Viruses Will Spread from Animals to . . .
    Bats are a logical place to look if you want to predict spillovers SARS-CoV-2 almost certainly came from bats—perhaps reaching humans through an intermediary animal, such as a pangolin—as did
  • Novel SARS-CoV-2 outbreak and COVID19 disease; a systemic . . .
    Nearly half of the novel SARS-CoV-2 infection remains asymptomatic and poses a risk to others as a potential carrier of the virus 6 These asymptomatic infections also bypass rapid tests such as serum antibody tests COVID19 The novel SARS-CoV-2 infection primarily affects the respiratory airway and binds hACE2 receptor present on mucosal cells
  • In vitro selection and analysis of SARS-CoV-2 nirmatrelvir . . .
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes a main protease (M pro, nsp5, 3CL pro) that is essential for virus replication (1, 2) M pro cleaves coronavirus polyprotein 1a and 1ab at 11 junctions with a conserved Gln residue at the P1 site, a feature with no known human analogs (3–5)
  • Civet (Animal) - an overview | ScienceDirect Topics
    Data are accumulating and scientists believe that the SARS-CoV-2 may follow a similar path like SARS-CoV Cats, dogs, and ferrets are susceptible to SARS-CoV-2 according to natural infections history and experimental results All of the studies suggest a diversified host range might be involved in the SARS-CoV-2 pandemic outbreak





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