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  • Variant of Uncertain Significance (VUS)
    When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
  • I have a VUS (Variant of Uncertain Significance) Now what? - Mayo
    Important advice on your VUS: • Do not assume the worst • Having a VUS and a medical diagnosis does NOT mean they go together • Remember, we all have thousands of DNA variants and most are entirely unrelated to our health situations • There may be more harm done in wrongly assuming a VUS is harmless or harmful
  • Assessing a Variant of Uncertain Significance (VUS)
    Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation VUS
  • What Does Variant of Uncertain Significance (VUS) Mean?
    You may get a variant of uncertain significance (VUS) result This means the test found a mutation in one of the genes linked to inherited cancer, but it is not known if the mutation causes cancer 1 It is difficult to determine exactly what the impact of many genetic mutations will be
  • Variants of Uncertain Significance in Hereditary Disease . . .
    In general, VUS rates were highest in individuals who were not of European White descent (eg, Asian, Black, Hispanic, Native American, Pacific Islander, and Sephardic Jewish) and in genes associated with disorders of incomplete penetrance





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