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  • Leveraging ancestral sequence reconstruction for protein . . . - Nature
    Matthews et al present a protein sequence embedding based on data from ancestral sequences that allows machine learning to be used for tasks where training data are scarce or expensive
  • Ancestral sequence reconstruction for protein engineers
    Ancestral sequences are reconstructed by inferring a phylogenetic relationship between modern homologs and applying a statistical model of amino acid substitution to calculate sequences at internal nodes of the phylogenetic tree (Figure 1 a) When performing ASR, protein engineers should understand how the selection of input sequences (including number and diversity), evolutionary models, and





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