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  • Biologic therapy for autoimmune diseases: an update - PMC
    For refractory pemphigus vulgaris (PV), the recommended treatment is IV infusion of 375 mg m 2 rituximab once weekly in weeks 1, 2, and 3 of a 4-week cycle, which is repeated for one additional cycle, followed by one dose per month for 4 months (total of ten doses in 6 months) The initial infusion should be started at 50 mg hour, and if there
  • Is Immunotherapy Safe in Patients With Autoimmune Disease?
    Immune checkpoint inhibitors can be considered in patients with advanced cancer and pre-existing autoimmune diseases appropriate for anti–PD-1 therapy It is difficult to extrapolate the findings from retrospective studies to patients with the most severe, active, and life-threatening autoimmune disease conditions; rather, prospective data
  • Non-biologic immunosuppressive drugs for inflammatory and . . .
    The initial dose depends on disease severity and varies between 2 5 and 5 mg kg BW day administered twice day, which can also be applied for children 13 In overweight patients, it is recommended to use the ideal body weight rather than the actual body weight to avoid the risk of toxicity 12 To ensure drug absorption, clinicians generally
  • The promise of low-dose interleukin-2 therapy for autoimmune . . .
    In the trials of low-dose IL-2 reviewed here, the single dose varies from 0 09 to 5 4 MIU and the cumulative dose ranges from 1 5 to 52 5 MIU, except for a few patients with chronic GVHD who
  • Low-dose IL-2 therapy in autoimmune diseases: An update . . .
    Low-dose interleukin-2 (IL-2) is a potential treatment for autoimmune diseases IL-2 is a protein that helps regulate the immune system, and low doses of it can activate regulatory T cells (Tregs), which help control the immune response This can be beneficial in autoimmune diseases where the immune system attacks healthy tissues
  • Simplified regimen of combined low-dose rituximab for . . .
    Background Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting antibodies Rituximab is a second-line choice for the treatment for AE with NSAbs, which can cause B cell depletion via targeting CD20 However, the optimal protocol and dosage of rituximab combined with first-line therapy for NSAbs-associated AE remains unclear
  • Immunotherapy in patients with autoimmune disease - PMC
    The median duration of the pre-existing autoimmune disorder was 20 years with 30% of patients having received previous immunosuppressive therapy Only 3 2% of cases were on active immunosuppressive therapy at the time of initiation of the ICI The study showed that flares from a pre-existing autoimmune condition were common (n=47; 42%)





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