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  • CD37 Gene - GeneCards | CD37 Protein | CD37 Antibody
    CD37 (CD37 Molecule) is a Protein Coding gene Diseases associated with CD37 include Mantle Cell Lymphoma and Diffuse Large B-Cell Lymphoma Among its related pathways is TYROBP causal network in microglia An important paralog of this gene is CD82
  • 靶向CD37的药物研发现状医药新闻-ByDrug-一站式医药资源 . . .
    CD37 在成熟 B 细胞上选择性表达，在其他造血细胞如 T 细胞和 NK 细胞、粒细胞、单核细胞和树突细胞上表达有限或不表达。 此外，它通过与 SOCS3 的相互作用控制 IL-6 受体信号传导。
  • 靶向CD37的药物研发现状 01 CD37靶点介绍CD37 是一种四 . . .
    Betalutin通过靶向肿瘤细胞表面的CD37蛋白，内化至肿瘤细胞中，使其细胞核长期暴露于核素的放射性辐射下，破坏肿瘤细胞DNA并导致死亡。 这种新型靶向CD37的治疗手段为传统CD20抗体药物耐药的非霍奇金淋巴瘤患者提供了一种新的选择。 2020年NordicNanovector公司在Blood Advances上发表了其靶向CD37抗体-放射性核素偶联疗法--Betalutin治疗复发 难治性非霍奇金淋巴瘤的1 2a期临床积极结果。 结果显示：中位随访24 5个月时所有74位患者中，总体缓解率（ORR）为61％，包括30％的完全缓解（CR）， 31%的部分缓解PR,以及19% 的SD 。
  • CD37 in B Cell Derived Tumors—More than Just a Docking Point . . . - MDPI
    CD37 is a tetraspanin expressed prominently on the surface of B cells It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical
  • CD37 in acute myeloid leukemia: a novel surface target for drug . . .
    Our work revealed that the clinically relevant anti-CD37 antibody–drug conjugate (ADC) Debio 1562 (αCD37-DM1) is highly cytotoxic to AML blasts, but not normal hematopoietic stem cells We found that αCD37-DM1 improved clinical outcomes and overall survival in multiple in vivo models of AML
  • Gene - CD37 - maayanlab. cloud
    CD37 molecule: Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains
  • Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 . . . - PubMed
    A novel mouse monoclonal anti-human CD37 antibody (clone 2B8D12F2D4) was generated with high binding affinity for CD37 antigen (KD = 1 6 nM) The CD37 antibody specifically recognized cell surface CD37 protein in lymphoma cells and not in multiple myeloma or other types of cancer
  • Anti-CD37 Antibodies | Invitrogen - 赛默飞世尔科技公司
    Find the CD37 antibody that fits your needs Choose from 1 of 23 CD37 antibodies, which have been validated in experiments with 3 publications and 42 images featured in our data gallery Browse primary antibodies for WB, Flow, IHC, ICC IF, ELISA, IP, and other applications Antibodies with Advanced


















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