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Anaesthetic management of a known or suspected malignant . . .
Congenital myopathy RYR1 is the principal gene associated with MH susceptibility; variants in the gene are estimated to contribute to 75% of MH cases 7 However, variants in the RYR1 gene are associated with other phenotypes, the most established of which are various forms of congenital myopathy, notably the core myopathies (so named because of lack of oxidative enzyme staining producing
Malignant hyperthermia 2020 - Hopkins - 2021 - Anaesthesia . . .
Anaesthesia for patients with an increased risk of developing malignant hyperthermia Patients at increased risk of developing MH must not be exposed to potent inhalational anaesthetics or suxamethonium The easiest way to avoid these agents is to avoid general anaesthesia by substituting a regional anaesthetic technique if appropriate
Malignant Hyperthermia - StatPearls - NCBI Bookshelf
Pathophysiology Malignant hyperthermia is an autosomal dominantly inherited disorder characterized by skeletal muscle hypermetabolism following exposure to halogenated anesthetics, depolarizing muscle relaxants such as succinylcholine, or, occasionally, physiologic stressors
Anesthesia-induced rhabdomyolysis or malignant hyperthermia . . .
Anesthesia-induced rhabdomyolysis and malignant hyperthermia occur in response to the same agents and present with similar clinical features Distinguishing between these diagnoses can be challenging in a clinical crisis yet making the distinction is critical as prompt appropriate management may be life-saving, whereas delayed recognition and
Consensus guidelines on perioperative management of malignant . . .
Malignant hyperthermia is a potentially fatal condition, in which genetically predisposed individuals develop a hypermetabolic reaction to potent inhalation anaesthetics or succinylcholine Because of the rarity of malignant hyperthermia and ethical limitations, there is no evidence from interventional trials to inform the optimal perioperative management of patients known or suspected with
Malignant hyperthermia 2020 | Association of Anaesthetists
Malignant hyperthermia is defined in the International Classification of Diseases as a progressive lifethreatening hyperthermic reaction occurring during general anaesthesia Malignant hyperthermia has an underlying genetic basis, and genetically susceptible individuals are at risk of developing malignant hyperthermia if they are exposed to any
Malignant hyperthermia: Diagnosis and management of acute . . .
In one case reported to the Malignant Hyperthermia Association of the United States (MHAUS) hotline and confirmed by molecular genetic analysis, the patient had undergone approximately 30 general anesthetics prior to triggering MH (See "Malignant hyperthermia susceptibility: Evaluation and management", section on 'Anesthetic history' )