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  • Ibrutinib Resistance Mechanisms and Treatment Strategies for . . .
    BTK is a central contributor to B-cell lymphoma pathogenesis, as it is significantly more active (increased phosphorylation) in B-cell lymphomas than in normal B-cells Additionally, BTK plays a fundamental role in modulating chemokine and integrin signaling (CXCR4), thereby regulating B-cell trafficking and tissue homing [ 7 ]
  • Ibrutinib improves diffuse large B-cell lymphoma survival
    NCI researchers have found that adding the targeted therapy ibrutinib (Imbruvica) to standard chemotherapy can improve how long some younger people with a specific form of diffuse large B-cell lymphoma live The new findings come from a new analysis of a previously conducted phase 3 clinical trial called Phoenix
  • Imbruvica (Ibrutinib) | Lymphoma News Today
    A total of 56 patients with various types of B-cell NHL were enrolled in the study The results showed that Imbruvica was well-tolerated across various types of B-cell NHL The FDA approved Imbruvica in 2013 for the treatment of patients with MCL based on the results of an open-label Phase 2 trial (NCT01236391) During the trial, 111 patients
  • IMBRUVICA® (ibrutinib) | Official Patient Website
    The most common side effects of IMBRUVICA® in adults with B-cell malignancies (CLL SLL and WM) include low platelet count; diarrhea; tiredness; muscle, bone, and joint pain; low white blood cell count; rash; low red blood cell count (anemia); bruising; and nausea
  • Ibrutinib improves survival for younger people with diffuse . . .
    “This new analysis provides a compelling rationale for doctors to consider adding ibrutinib to standard chemotherapy for the initial treatment of younger patients with non-GCB DLBCL,” said Wyndham H Wilson, M D , Ph D , senior investigator in the Lymphoid Malignancies Branch and a co-author of the study DLBCL is the most common type of
  • Ibrutinib in Patients with Relapsed or Refractory Diffuse . . .
    Based on gene profiling, DLBCL can be further classified as activated B-cell-like lymphoma (ABC), germinal center B-cell-like lymphoma (GCB) and primary mediastinal B-cell lymphoma Most patients of DLBCL achieve complete remission (CR) after treatment with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), which is
  • Your Guide to Your IMBRUVICA (ibrutinib) Treatment Plan
    IMBRUVICA® may cause serious side effects, including: Infections can happen during treatment with IMBRUVICA® These infections can be serious and may lead to death Tell your healthcare provider right away if you have fever, chills, weakness, confusion, or other signs or symptoms of an infection during treatment with IMBRUVICA® B cell BTK
  • Imbruvica (Ibrutinib): First Drug Approved for the Treatment . . .
    In 2013, ibrutinib received accelerated approval for the treatment of patients with mantle-cell lymphoma who had received at least 1 previous therapy 10 In 2014, ibrutinib was approved for the treatment of patients with chronic lymphocytic leukemia (CLL) who received at least 1 previous regimen, and for patients with CLL with the 17p deletion 10


















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