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  • Morphine and biliary pain revisited - Gut
    With the gall bladder gone and the bile ducts (which lack a smooth muscle layer) acting as a simple conduit, the sphincter of Oddi (SO) becomes the prime suspect for the pain through spasm or biliary obstruction The sphincter, strategically located at the junction of the biliary tract, pancreas, and duodenum, is like a …
  • The Useage of Opioids and their Adverse Effects in Gastrointestinal . . .
    Numerous research has focused on the provision of new molecules that do not pass the blood-brain barrier that just have peripheral effects Morphine and morphine-like medications work mostly via the opioid μ receptor, which is responsible for the majority of opioid effects in the brain and periphery
  • [Morphine induced biliary pain. Case report] - PubMed
    This exaggerated response can manifest as a colicky biliary pain, frequently accompanied by a dramatic increase in hepatic enzymes We report a 32 years old female who consulted in the emergency room for severe low abdominal pain of gynecologic origin, which was completely controlled by morphine
  • OGBN P25 A systematic review and clinical evaluation of Morphine Versus . . .
    The most commonly recommended pharmaceuticals for biliary and pancreatic pain are arguably morphine and pethidine, both of which can elicit varying effects at the gallbladder, common bile duct, and sphincter of Oddi levels Morphine stimulates Oddi's sphincter motility, causing upper abdominal pain and biliary distress symptoms in certain patients
  • Morphine - StatPearls - NCBI Bookshelf - National Center for . . .
    Other effects include euphoria, dysphoria, agitation, dry mouth, anorexia, and biliary tract spasms, which is why some physicians will avoid morphine when patients present with right upper quadrant pain and suspect possible biliary tract pathology Morphine can also affect the cardiovascular system and reportedly can cause flushing, bradycardia
  • Opioid-induced gut microbial disruption and bile dysregulation leads to . . .
    Here, we show for the first time, using bacterial 16s rDNA sequencing, that chronic morphine treatment significantly alters the gut microbial composition and induces preferential expansion of gram-positive pathogenic and reduction in bile-deconjugating bacterial strains
  • Effect of Fentanyl and Morphine on Gallbladder Dimensions in Newborns . . .
    As an adverse effect in newborns that receive morphine or fentanyl as a premedication, morphine causes gallbladder dilatation more than fentanyl However, it should be noticed that TPN, which is commonly used the ICU, intensifies gallbladder dilatation
  • Effects of narcotic analgesic drugs on human Oddi’s sphincter motility
    Blaut et al found that morphine increased the intraductal biliary pressure (IDP) with OSM via a T-tube, but the high intraductal biliary pressure caused by morphine could be counteracted by transcutaneous electrical nerve stimulation (TENS)





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