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  • Distinct clusters of human pain gene orthologs in . . .
    Overall, our data show that genetic alterations among human pain gene orthologs can produce a broad spectrum of nociceptive adaptation abnormalities in C elegans, with several genes modulating specific aspects of the nociceptive plasticity phenomenon
  • C. elegans : A Model for the NE-Mediated Modulation of . . .
    Together these observations suggest that understanding the OA-dependent modulation of aversive behavior in C elegans may provide useful mechanistic insights into the modulation of chronic pain in mammals
  • Thermal avoidance in Caenorhabditis elegans: An approach to . . .
    To evaluate whether C elegans could be used as a new model to study the molecular basis of heat perception, we also tested the influence of chemical compounds used in pain research Our results suggest that the response of C elegans and vertebrates to noxious heat can be manipulated pharmacologically by the same chemicals and, therefore
  • Neuronal responses to stress and injury in C. elegans - PMC
    Caenorhabditis elegans has served as an excellent model to discover fundamental mechanisms underlying the neuronal response to stress The basic physiological processes that C elegans exhibits under stress conditions are similar to those observed in higher organisms
  • Behavioral response of Caenorhabditis elegans to localized . . .
    Through high resolution quantitative behavioral analysis, we have comprehensively characterized the C elegans escape response to noxious thermal stimuli applied along its body, and found a novel midbody response
  • 14 The Journal of Pain Abstracts Genetic Characterization and . . .
    Our lab pioneered the development of a cross-species transgenic Caenorhabditis elegans model expressing mammalian MOR (tgMOR) that yields opioid-induced behavior as its primary readout At present, we do not fully understand how tgMOR uti-lizes endogenous conserved signaling components to generate opioid-induced behavioral effects





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