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  • About Flavoring-related Lung Disease | Flavorings | CDC
    Diacetyl and its substitute, 2,3-pentanedione (acetyl propionyl), are flavoring chemicals used in food flavoring and production industries These include microwave popcorn, bakery mix, and flavored coffee industries Workplace exposure to diacetyl has been associated with severe respiratory impairment
  • Exposure Control and Prevention | Flavorings | CDC
    Eliminate exposures by not using diacetyl and 2,3-pentanedione when possible Substitute by using less hazardous chemicals Carefully evaluate substitutes for toxicity before using Use engineering controls such as closed systems, isolation, or local exhaust ventilation
  • Docket 245: Occupational Exposure to Diacetyl and 2,3-pentanedione . . .
    Previously, NIOSH held a public meeting on August 26, 2011 in Washington, DC to discuss and obtain comments on the draft document, “Criteria for a Recommended Standard: Occupational Exposure to Diacetyl and 2,3-Pentanedione” which was released in August 2011 Public comments on the draft document were received for submission to this docket
  • E-Cigarette Use Among Youth | Smoking and Tobacco Use | CDC
    Overview In the United States, youth use e-cigarettes, or vapes, more than any other tobacco product 1 No tobacco products, including e-cigarettes, are safe, especially for children, teens, and young adults 2
  • NIOSH [2015]. Best practices: engineering controls, work practices and . . .
    areas to reduce workers’ exposures to diacetyl through engineering controls, best work prac-tices, and techniques for monitoring airborne diacetyl exposures Although these guidelines emphasize diacetyl, they can be applied to reduce exposures to diacetyl substitutes such as 2,3-pentanedione and other alpha-diketones
  • About E-Cigarettes (Vapes) | Smoking and Tobacco Use | CDC
    Flavorings such as diacetyl, a chemical linked to a serious lung disease Some flavorings used in e-cigarettes may be safe to eat but not to inhale because the lungs process substances differently than the gut It is difficult to know which substances e-cigarettes contain
  • NIOSH Skin Notation Profile Diacetyl and 2,3-Pentanedione
    sure to diacetyl and 2,3-pentanedione and the potential for direct skin injuries from diacetyl and 2,3-pentanedione A literature search was conducted through March 2021 to identify information on diacetyl and 2,3-pentanedione dermal absorption, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biolog-
  • Monitoring for Occupational Exposures to Diacetyl and 2,3-Pentanedione . . .
    Although these guidelines emphasize diacetyl, they can be applied to reduce exposures to diacetyl substitutes such as 2,3-pentanedione and other alpha-diketones Best Practices: Engineering Controls, Work Practices, and Exposure Monitoring for Occupational Exposures to Diacetyl and 2,3-Pentanedione [PDF – 1 5 MB]





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