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  • Enhancing anti-tumor immunity of natural killer cells through targeting . . .
    Key hits included the NEDD8 E2-conjugating enzyme UBE2F, the ubiquitin E3-ligase ARIH2, and Cullin-5 RING E3 ligase (CRL5) members We found that UBE2F was required for neddylation and activation of CUL5, whereas ARIH2 contributed to CRL5-mediated IL-15RB degradation
  • Making NK Cells Target Cancer by Increasing IL-15 Sensitivity
    When switched off in NK cells, the genes ARIH2 and UBE2F, which code for the two enzymes Ariadne RBR E3 ubiquitin protein ligase 2 (ARIH2) and ubiquitin-conjugating enzyme (UBE2F), make NK cells more sensitive to interleukin-15 (IL-15), even in low amounts
  • GSE296451 - UBE2F inhibits Natural Killer cell tumor immunity by . . .
    In mice lacking Arih2, Rnf7 or Ube2f, IL-15R hyperresponsive NK cells resulted in superior in vivo anti-tumor immunity against primary and disseminated metastatic tumors Thus, we have identified the enzymes UBE2F and ARIH2 as tractable immunotherapy drug targets
  • UBE2F Gene - GeneCards | UBE2F Protein | UBE2F Antibody
    UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene Diseases associated with UBE2F include Three M Syndrome 1 Among its related pathways are Class I MHC mediated antigen processing and presentation and Metabolism of proteins
  • Bulk and single-cell RNA sequencing identify prognostic signatures . . .
    As a specific immune cell subpopulation, FGFBP2 + NK cells play a crucial part in immune surveillance of HCC progression This study set out to identify prognostic signature related to FGFBP2 + NK cell in HCC Bulk and scRNA-seq data were derived from the public databases
  • UBE2F protein expression summary - The Human Protein Atlas
    UBE2F is a prognostic marker in Head and neck squamous cell carcinoma, Liver hepatocellular carcinoma
  • Enhancing anti-tumor immunity of natural killer cells through targeting . . .
    In mice lacking Arih2, Rnf7, or Ube2f, we observed that the IL-15R hyperresponsive NK cells exhibited superior in vivo anti-tumor immunity against primary and disseminated metastatic tumors Thus, we have identified the enzymes UBE2F and ARIH2 as tractable immunotherapy drug targets
  • 靶向UBE2F-CRL5通路增强NK细胞抗肿瘤免疫的新策略 - 生物通
    这项研究中，科学家们通过全基因组CRISPR筛选技术，在自然杀伤细胞 (NK)中发现：UBE2F依赖的Cullin-5 RING E3连接酶 (CRL5)复合物活化会导致IL-15受体 (IL-15R)降解并抑制其信号传导。 靶向UBE2F能显著增强NK细胞的抗肿瘤免疫力。 IL-15R表达水平直接影响细胞毒性免疫细胞功能 CRISPR筛选揭示CRL5依赖的降解抑制IL-15R信号 敲除UBE2F可抑制CRL5活性，提升NK细胞对IL-15的响应 UBE2F缺失能增强CAR-NK细胞和内源性抗实体瘤免疫 白细胞介素-15受体 (IL-15R)激动剂在临床前模型中显示出抗肿瘤免疫活性，但剂量限制性毒性阻碍了其临床应用。
  • The CUL5 ubiquitin ligase complex mediates resistance to CDK9 . . . - eLife
    Drug treatment greatly reduced colony-forming ability in the CUL5 and UBE2F knockout cells, indicating efficient and persistent resensitization of these cells Taken together, multiple lines of evidence indicate that the resistance of LK2 cells to both CDK9 and MCL1 inhibition can be overcome by depletion of the CRL5 complex
  • Supplemental information Enhancing anti-tumor immunity of natural . . .
    expression in whole NK cell lysates of AAVS1, UBE2F, CISH UBE2F+CISH deleted primary human NK cells expanded in IL-15 was determined by western blotting (SS = serum starved; 0h - 3h = time post pulse with 20 ng mL IL-15 for 15 min)





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