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  • Bayesian Optimal Interval (BOIN) Design for Phase I Clinical Trials
    BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials JCO Clinical Cancer Informatics, 5, 91-101 Cite the software: Zhou, Y , Liu, Y , Yuan, Y , Lee, J J , Zhou, H , Chen, N , Kuo, Y (2026) Bayesian Optimal Interval (BOIN) Design for Phase I Clinical Trials (V3 0 17 0) [Computer software]
  • An overview of the BOIN design and its current extensions for novel . . .
    Bayesian Optimal Interval (BOIN) designs are a class of model-assisted dose-finding designs that can be used in oncology trials to determine the maximum tolerated dose (MTD) of a study drug based on safety or the optimal biological dose (OBD) based
  • Trial Design
    Time-to-Event BOIN (TITE-BOIN) allows for real-time dose assignment for new patients while some enrolled patients’ toxicity data are still pending, thereby significantly shortening the trial duration It is as easy to implement as the rolling 6 design, but yields much better performance
  • Statistical Tutorial for Using Bayesian Optimal Interval (BOIN) Design . . .
    Liu S and Yuan, Y (2015) Bayesian Optimal Interval (BOIN) Designs for Phase I Clinical Trials, Journal of the Royal Statistical Society: Series C, 64, 507-523
  • CRAN: Package BOIN
    The Bayesian optimal interval (BOIN) design is a novel phase I clinical trial design for finding the maximum tolerated dose (MTD) It can be used to design both single-agent and drug-combination trials
  • Everything You Need to Know About BOIN Design in Clinical Trials
    Bayesian Optimal Interval (BOIN) design are growing in popularity due to their statistical robustness, practical applicability and simplicity Learn more
  • Francesco Boin | About | Cedars-Sinai Medical Center
    Dr Boin is a physician-scientist with extensive experience in the diagnosis and treatment of scleroderma and other fibrosing skin disorders His research is focused on the genetic risk of scleroderma and the biology of immune cells involved in the pathogenesis of this disease
  • An overview of the BOIN design and its current extensions for novel . . .
    BOIN designs provide a complete suite for dose finding in early phase trials, and a consistent way to explore different scenarios in a unified manner with easy access to software [1] to implement most of these designs
  • Dr. Francesco Boin, MD, Rheumatologist | Los Angeles, CA | WebMD
    Dr Francesco Boin specializes in rheumatology, bringing 33 years of experience to the diagnosis and treatment of arthritis, autoimmune conditions, and other disorders affecting joints, muscles,
  • Approval [Rx ONLY]
    Goal and Intended Applications The BOIN design is a statistical methodology for phase I dose finding clinical trials where the goal is to find the maximum tolerated dose (MTD) of a new drug





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