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  • Myelodysplastic syndromes: Updates on Genomic Landscape . . .
    Purpose of Review Advances in modern molecular and genomic testing have spurred tremendous progress in our understanding of MDS pathogenesis Here we review common diagnostic methods, the evolving multi-omics landscape of MDS, molecular subtypes, and targeted therapies Recent Findings MDS is a heterogeneous disease defined by a wide array of chromosomal abnormalities and > 40 common somatic
  • A New Cellular Immunotherapy Approach May Offer Treatment for . . .
    Laboratory research shows how it may be possible to develop an immunotherapy-based approach for treating aggressive forms of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)
  • Whats New in Myelodysplastic Syndrome (MDS) Research?
    As researchers have learned more about the gene changes inside MDS cells, they’ve started to test drugs that target some of these changes An example is ivosidenib (Tibsovo), which can now be used to treat MDS when the cells have an IDH1 gene mutation Many other targeted therapy drugs are now being studied for use against MDS as well
  • Genetics of MDS | Blood | American Society of Hematology
    Myelodysplastic syndromes (MDS) comprises a heterogeneous group of myeloid neoplasms, which are characterized in common by manifestations of bone marrow failure with abnormal cell morphology and a high propensity to acute myeloid leukemia (AML) 1, 2 Now, it is well recognized that MDS is, like other cancers, shaped by recursive rounds of positive selections, where gene mutations and other
  • Myelodysplasia after Lentiviral Gene Therapy | New England . . .
    To the Editor: Duncan et al (Oct 10 issue)1 report the occurrence of myelodysplastic syndrome in approximately 10% of patients with cerebral adrenoleukodystrophy who received autologous hematopoi
  • Hotspot gene mutations and treatment response in . . . - Frontiers
    Abstract The myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by cytopenia and a high risk of transformation to acute myeloid leukemia In recent years, next-generation sequencing (NGS) has revealed common hotspot gene mutations in MDS, which are not only involved in disease progression, but also affect the responsiveness of different therapeutic
  • Target therapy adoption for myelodysplastic syndromes (MDS . . .
    This study evaluates MT use in first-line therapy decisions and its impact on treatment for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) Methods: This retrospective study analyzed genomic data from July 2018 to December 2023, sourced from NeoGenomics Laboratories and linked with Symphony administrative claims data
  • Myelodysplastic syndromes - Diagnosis and treatment - Mayo Clinic
    Medications that suppress or control your immune system are used in certain myelodysplastic syndromes to reduce your need for red blood cell transfusions Help people with a certain genetic abnormality If your myelodysplastic syndrome is associated with a gene mutation called isolated del (5q), your doctor might recommend lenalidomide (Revlimid)
  • CAR-T Cell Therapy for MDS Faces Barriers - Hematology Advisor
    The development of chimeric antigen receptor (CAR) T-cell therapy is significantly changing immunotherapy for hematologic malignancies However, problems of resistance and toxicity remain significant barriers in the treatment of myelodysplastic syndromes (MDS)





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