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  • The sirtuin family in health and disease
    Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous
  • Sirtuin - Wikipedia
    Sirtuins are a family of signaling proteins involved in metabolic regulation [2] [3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life [2]Chemically, sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and
  • Role of Sirtuins in Physiology and Diseases of the Central Nervous . . .
    Silent information regulators, sirtuins (SIRTs), are a family of enzymes which take part in major posttranslational modifications of proteins and contribute to multiple cellular processes, including metabolic and energetic transformations, as well
  • The role and therapeutic potential of SIRTs in sepsis - PMC
    In recent years, the Sirtuins (SIRTs) family has been found to play an important role in the pathogenesis of sepsis SIRTs, as a class of histone deacetylases (HDACs), are widely involved in cellular inflammation regulation, energy metabolism and oxidative stress
  • Sirtuins as therapeutic targets in diabetes - PubMed
    Introduction: Sirtuins (SIRTs) are NAD +-dependent deacetylases that mediate post-translational modifications of proteins Seven members of the SIRT family have been identified in mammals Importantly, SIRTs interact with numerous metabolic and inflammatory pathways





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