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  • Resistance to single-agent chemotherapy in low-risk . . .
    This study demonstrated higher tumor size, the occurrence of metastasis, and pretreatment β-HCG levels have been associated with increased resistance to first-line chemotherapy agents Key Words: Single-agent chemotherapy, Gestational trophoblastic neoplasia, Dactinomycin, Methotrexate, Treatment failure
  • Recurrence and resistance risk factors in low-risk . . . - PubMed
    To enhance the understanding of the mechanisms driving treatment failures and to develop more personalized and effective therapeutic strategies, this review explored diverse factors influencing low-risk GTN prognosis
  • Resistance to single-agent chemotherapy and its risk factors . . .
    In our study, patients with a score of 5 and 6, which is commonly known as the intermediate risk group, had a 14-fold higher risk of resistance to single-agent chemotherapy, compared with the low-risk group (score, ≤4)
  • Hysterectomy versus chemotherapy for low-risk non-metastatic . . .
    Single agent chemotherapy cost, risk of resistance, and chemotherapy duration are key factors impacting treatment costs Determine the cost-effectiveness for hysterectomy versus standard of care single agent chemotherapy for low-risk gestational trophoblastic neoplasia (GTN)
  • Resistance to single-agent chemotherapy in low-risk . . .
    Although low-risk GTN is considered a curable disease, its reported primary remission rates of 49 to 93% reflect the difficulties of treatment and different factors influencing it Hence, this study aimed to determine the remission rates and related factors of single-agent chemotherapy resistance in low-risk GTN patients
  • Hysterectomy versus chemotherapy for low-risk non-metastatic . . .
    Single agent chemotherapy cost, risk of resistance, and chemotherapy duration are key factors impacting treatment costs Determine the cost-effectiveness for hysterectomy versus standard of care single agent chemotherapy for low-risk gestational trophoblastic neoplasia (GTN)
  • Efficacy and Risk Factors Associated to Resistance to Single . . .
    WHO score was significantly associated with the risk of resistance to single-agent chemotherapy Other variables included in the WHO as age, antecedent pregnancy, pre-treatment hCG, tumour size and FIGO stage were not significantly associated with resistance We report five fatal cases





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