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  • Serious infections in patients with systemic lupus erythematosus: how . . .
    Among 1048 patients with SLE (746 [71%] treated with rituximab, 119 [11%] treated with belimumab, and 183 [17%] on standard of care), 118 serious infections occurred in 76 (7%) patients during the first year after inclusion in the registry
  • Systemic lupus erythematosus and infections - PubMed
    Moreover, SLE patients exhibit an increased susceptibility to hospital-acquired infections Factors associated with increased risk of infections include high disease activity, specific immune dysregulation, drug-induced immune deficiency, and organ failure with irreversible damage
  • Managing infections: systemic lupus erythematosus patients | OARRR
    To reduce the risk of infections in SLE and their complications, providers should apply strategies of glucocorticoids dose reduction and judicious use of immunosuppressive and targeted biological therapies with treatment to target approaches 5 Novel therapeutics in SLE, though safer and efficacious in controlling disease activity and in achievi
  • risk of infections in adult patients with systemic lupus erythematosus . . .
    Well-designed trials and observational studies are needed to support the management and prevention of infection in patients with SLE, including identification of patients at high risk of infection and those who would benefit from vaccination, or patient monitoring to mitigate risk
  • How can we reduce the risk of serious infection for patients with . . .
    Many infections in patients with SLE could be prevented with timely vaccinations, reducing exposure to contagious contacts, screening for latent infections, minimizing exposure to corticosteroids, targeted prophylaxis for high risk patients, and, unless contraindicated, anti-malarial therapy as standard of care
  • Management of infection in systemic lupus erythematosus
    There are various strategies which can be applied to try and reduce the risk of infection in SLE patients Options include vaccinations, antibiotic antiviral prophylaxis and intravenous immunoglobulins Keywords: Bacterial viral fungal flare; Immunoglobulin; Vaccination; Vaccine antibiotic prophylaxis Copyright © 2013 Elsevier Ltd
  • Management of infection in systemic lupus erythematosus
    There are various strategies which can be applied to try and reduce the risk of infection in SLE patients Options include vaccinations, antibiotic antiviral prophylaxis and intravenous immunoglobulins Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal autoantibody production and clearance
  • Prophylactic use of antibiotics and immunisations in patients with SLE
    Doctors caring for patients with SLE are left to answer the vexing question: how do we control the inflammation related to disease activity without in-creasing the infection rate?
  • The risk of infections in adult patients with systemic lupus . . .
    Well-designed trials and observational studies are needed to support the management and prevention of infection in patients with SLE, including identification of patients at high risk of infection and those who would benefit from vaccination, or patient monitoring to mitigate risk
  • The role of probiotics in promoting systemic immune tolerance in . . .
    Systemic lupus erythematosus (SLE) is an autoimmune disorder branded via over-activation of the immune system, resulting in atypical roles of natural and adaptive immune cells and the making of numerous autoantibodies against nuclear components The causes and pathogenesis of this disease are not completely realized The gut microbiota plays a significant character in human health and disorder
  • Prophylactic use of antibiotics and immunisations in patients with SLE
    Doctors caring for patients with SLE are left to answer the vexing question: how do we control the inflammation related to disease activity without increasing the infection rate?
  • A Framework to Overcome Challenges in the Management of Infections in . . .
    Clinicians report challenges and barriers when encountering infection in SLE as certain infections may mimic a lupus flare There are no evidence-based practice guidelines in the management of fever in SLE, with suboptimal implementations of evidence-based benefits related to infectious disease control and or prevention strategies in SLE
  • Systemic Lupus Erythematosus and Immunodeficiency - PMC
    Clinical awareness, appropriate assessment, and management are essential to minimize infective complications This article serves to update the current understanding of SLE and immunodeficiency by discussing the shared genetic factors and immunobiology
  • Clinical characteristics and risk factors of infection in patients with . . .
    In addition, glucocorticoids (especially high-dose) and immunosuppressants (e g cyclophosphamide) rendered SLE patients more susceptible to infection, while antimalarial drug administration (hydroxychloroquine) was a protective factor against infection in SLE patients
  • A Framework to Overcome Challenges in the Management of Infections in . . .
    Infections remain one of the leading causes of death in systemic lupus erythematosus (SLE), despite awareness of factors contributing to increased susceptibility to infectious diseases in SLE Clinicians report challenges and barriers when





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