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  • Mesenchymal stromal stem cell (MSC)-derived exosomes in clinical trials
    In addition, MSC-derived exosomes (MSC-Exos) can recapitulate the biological potential of MSCs; therefore, they may substitute for cell therapy to achieve cell-free therapy [13, 14] The advantages of exosome utilization, when compared to their cellular counterparts, include a higher safety profile mainly due to their nanoscale size
  • Clinical applications of stem cell-derived exosomes
    MSC-derived exosomes can manage viral infection and lung damage in COVID-19 through both reparative actions and regenerative effects 337 The former manifests as blockage of viral entry and
  • Biology and therapeutic potential of mesenchymal stem cell‐derived exosomes
    Figure 1 illustrates the intracellular composition, release and uptake of MSC exosomes Figure 1 Open in a new tab Biogenesis, secretion and molecular composition of the mesenchymal stem cell (MSC)‐derived exosomes A, Exosome biogenesis, secretion and uptake by recipient cells First, multiple proteins were internalized from the cell
  • Mesenchymal stem cell-derived exosomes: Characteristics and . . .
    MSC-exos possess the same physical traits, storage techniques, and separation processes as exosomes from other origins When it comes to exosome characterization, MSC-based exosomes exhibit MSC surface markers including CD29, CD73, CD90, and CD44 in addition to more widespread surface indicators like CD9 and CD81
  • Mesenchymal stromal stem cell (MSC)-derived exosomes in . . . - PubMed
    Compared to MSCs themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started to assess the therapeutic effect of MSC
  • Mesenchymal stem cell derived-exosomes: a modern approach in . . .
    Therefore, MSC-derived exosomes can be manipulated and applied to establish a novel cell-free therapeutic approach for treatment of a variety of diseases including heart, kidney, liver, immune and neurological diseases, and cutaneous wound healing In comparison with their donor cells, MSC-derived exosomes offer more stable entities and
  • Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes: From Basic . . .
    Composition of Mesenchymal stem cells- exosomes (MSC-Exos) and their role in MSC-Exo-mediated biological effects MSC-Exos contain a large number of biologically active molecules (lipids, proteins (enzymes, cytokines, immunoregulatory proteins, growth factors, and miRNAs) which are responsible for MSC-Exo-based therapeutic effects
  • Mesenchymal Stem Cells vs Exosomes: A Comparison Summary from the . . .
    Exosome therapy has performed well in animal models of cancer and inflammatory conditions These studies demonstrated that exosome therapy could be harnessed to reduce tumor growth (exosomes loaded with anticancer agents) or decrease inflammation (MSC exosomes) in the respective disease model





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