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  • Aging and age‐related diseases: from mechanisms to therapeutic . . .
    Anti‐aging drugs Anti-aging is a very promising and yet challenging field, which is complicated by the mechanisms of aging Some FDA approved drugs target one or more molecules to reduce cellular damage and prolong the healthspan
  • Human trials exploring anti-aging medicines - ScienceDirect
    Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories
  • Anti-ageing effects of FDA-approved medicines: a focused review
    This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found that alogliptin, canagliflozin and metformin might produce anti-ageing activity via AMPK activation Rapamycin and canagliflozin are capable to inhibit mTOR to promote lifespan
  • Identification of prospective aging drug targets via Mendelian . . .
    To explore potential side effects linked to our therapeutic target gene, we conducted phenome-wide MR analyses Utilizing pQTL data for the aging-target protein as the exposure and contrasting this with aggregated genome-wide association study (GWAS) data on various diseases from the UK Biobank cohort ( n = 408,961) as the outcome, we aimed to
  • Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and . . .
    Polypharmacy increases the risk of adverse drug events, drug interactions, drug–disease interactions, poor regimen adherence, and an onslaught of geriatric syndromes, such as falls, cognitive decline, delirium, and frailty (7)
  • Anti-Aging Drugs and the Related Signal Pathways - PMC
    According to the underlying mechanisms, this review summarized six representative types of compounds that target important aging-related signal pathways, including rapamycin, metformin, acarbose, NMN, lithium, and nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Basic pathways and targets for anti-aging intervention
    Numerous studies use the term anti-aging—or prolongevity pathway to describe how the activation of AMPK and SIRT1 enhance healthy aging and increase longevity, while the term proaging pathway is used to illustrate how activation of mTOR and IGF1 reduce healthy aging and decrease longevity
  • Repurposing of Drugs in Aging - SpringerLink
    This abstract reviews the current state of knowledge on repurposed drugs for anti-aging purposes It highlights the advantages of repurposing over traditional drug discovery, such as reduced cost, shorter development timelines, and known safety profiles
  • Anti-Aging Drugs and the Related Signal Pathways - MDPI
    According to the underlying mechanisms, this review summarized six representative types of compounds that target important aging-related signal pathways, including rapamycin, metformin, acarbose, NMN, lithium, and nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Health Benefits of Anti-aging Drugs - PubMed
    Resveratrol, rapamycin, metformin and aspirin, showing effectiveness in model organism life- and healthspan extension mainly target the master regulators of aging such as mTOR, FOXO and PGC1α, affecting autophagy, inflammation and oxidative stress
  • Antiaging agents: safe interventions to slow aging and healthy life . . .
    The criteria for a potential anti-aging drug are: (1) a drug that extends the lifespan of a model organism, preferably a mammal; (2) a drug that delays or prevents some aging-related diseases in mammals; and (3) a drug that inhibits the senescence transition of cells from quiescence to senescence
  • DRADTiP: Drug repurposing for aging disease through drug-target . . .
    In this work, we designed a novel drug repurposing model by identifying the interaction between aging-related genes or targets and drugs similar to aging disease Each disease is associated with certain specific genetic factors for the occurrence of that disease
  • Aging: therapeutics for a healthy future - PMC - PubMed Central (PMC)
    To some extent, perhaps aging is already being treated, with drugs targeted to specific diseases, such as Metformin for hyperglycemia and aspirin to reduce cardiovascular disease risk These and a number of other drugs commonly used to treat chronic disease conditions have been found to extend lifespan in lower organisms and in mice
  • Longevity Enthusiasts Embrace Diabetes Drug Class SGLT2 Inhibitors as . . .
    The widely used class of drugs, called SGLT2 inhibitors and sold under brand names such as Jardiance and Farxiga, have been on the market for over a decade as Type 2 diabetes medications They
  • Anti-Aging Drugs and the Related Signal Pathways - PubMed
    This review summarized these important aging-related signal pathways and their representative targeting drugs in attempts to obtain insights into and promote the development of mechanism-based anti-aging strategies





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